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(2006 - 2010)
Threshold relaxation is an effective means to connect gaps in
3D images of complex microvascular networks.
J. Kaufhold, P. S. Tsai, P. Blinder and D. Kleinfeld. In Proceedings of the 3rd
Workshop on Microscopic Image Analysis with Applications in Biology
(in conjunction with MICCAI 2008)
PDF (4.8 Mb)
Dynamics and resilience of blood flow in cortical
microvessels. D. Kleinfeld.
In Proceedings of a Workshop on Statistics on Networks, National Research Council,
The National Academies Press, Washington, DC (2007)
pp 292-316 PDF (2.4 Mb)
Dynamics and resilience of blood flow in cortical
microvessels revealed with optical imaging and manipulations.
D. Kleinfeld. In Proceedings of the Fifth Inter-Institute
Workshop on "Optical Diagnostic Imaging from Bench to Bedside",
National Institutes of Health, Bethesda, MD (2006). http://videocast.nih.gov/ram/17Kleinfeld.ram;
transcript PDF (0.1 Mb)
In vivo manipulation of biological systems with femtosecond
laser pulses. N. Nishimura, C. B. Schaffer and D. Kleinfeld.
In Proceedings of SPIE Vol. 6261 High-Power Laser Ablation
VI, (2006) pp 62611J. PDF
(1.0 Mb)
Applying optical imaging to study neurovascular coupling
in cerebral cortex: From populational scale to single-cell single-vessel
measurements. A. Devor, E. Hillman, N. Nishimura, I.
U. S. Narayanan, I. Teng, A. Dunn, D. Boas, D. Kleinfeld, A. Dale.
In Proceedings of the Optical Society of America, Biomedical
Optics meeting (BIOMED 2006), Fort Lauderdale, FL (2006).
PDF
(0.2 Mb)
Ultrafast third harmonic micro-spectroscopy reveals a
two-photon resonance in human hemoglobin. G. O. Clay,
C. B. Schaffer, J. A. Squier, and D. Kleinfeld. In Proceedings
of the SPIE/Photonics West (Commercial and Biomedical
Applications of Ultrafast Lasers VI, J. Neev, S. Nolte, A. Heisterkamp
and C. B. Schaffer, editors), San Jose, CA (2006) paper 6108-8. PDF
(0.4 Mb)
(2001 - 2005)
Ischemic islands in the infarct and penumbra after
MCA occlusion. B. Friedman, Q. Cheng, S. W. Yu, N. Nishimura,
C. B. Schaffer, F. F. Ebner, D. Kleinfeld and P. D. Lyden. Annals
of Neurology (2005) 58:S9.
Heterogeneous changes in blood flow in response to single
vessel blockages and MCA occlusions in rat parietal cortex as
revealed by in vivo two-photon laser imaging. B. Friedman,
N. Nishimura, C. B. Schaffer, D. Kleinfeld, and P. D. Lyden Stroke
(2004) 35:81. PDF
(0.1 Mb)
Targetted disruption of deep-lying neocortical microvessels
in rat using ultrashort laser pulses. N. Nishimura, C.
B. Schaffer, B. Friedman, P. S. Tsai, P. D. Lyden and D. Kleinfeld.
In Proceedings of the SPIE (Commercial and Biomedical
Applications of Ultrafast Lasers IV, J. Neev, C. B. Schaffer and
A. Osterdorf, editors), vol. 5340 (2004) pp 179-187.
PDF
(1.7 Mb) Featured in "Femtosecond laser pulses in biology:
From microscopy to ablation and micromanipulation" by M.
Arrigoni, Biophotonics International (June 2004) 48-51,
PDF
(0.7 Mb) and in "Micro-scalpel Offers Unprecedented Precision"
by K. Schmidt, New Scientist (25 March 2005) 40-45.
PDF
(1.0 Mb)
All optical histology: Serial ablation and multiphoton
imaging of neuronal tissue with femtosecond laser pulses.
P. S. Tsai, B. Friedman, V. Lev-Ram, C. B. Schaffer, Q. Xiong,
R. Y. Tsien, D. Kleinfeld, A. I. Ifarraguerri, B. D. Thompson
and J. A. Squier. In Proceedings of the Lasers and Electro-Optics
Society of the IEEE, Tuscon, AZ (2003). PDF
(0.2 Mb)
Real-time two-photon fluorescent microscopy of blood
flow dynamics following photothrombotic stroke in rat neocortex.
C. B. Schaffer, F. F. Ebner, N. Nishimura, B. Friedman, P. S.
Tsai, L. F. Schroeder, P. D. Lyden and D. Kleinfeld. In
Proceedings of the Lasers and Electro-Optics Society of the IEEE,
Tuscon, AZ (2003). PDF
(1.0 Mb)
Two-photon fluorescence microscopy of collateral blood
flow following photoyhtombotic stroke in rat neocortex.
C. B. Schaffer, F. F. Ebner, N. Nishimura, B. Friedman, P. S.
Tsai, L. F. Schroeder, P. D. Lyden and D. Kleinfeld. In
Proceedings of the Optical Society of America, Tuscon, AZ (2003).
PDF (0.9 Mb)
Customization of microfluidic devices using femtosecond
laser micromaching. T. N. Kim, A. Groisman, D. Kleinfeld
and C. B. Schaffer. In Proceedings of the Optical Society
of America, Tucson, AZ (2003). PDF
(1.0 Mb)
All optical histology of brain tissue: Serial ablation
and multiphoton imaging with femtosecond laser pulses.
P. S. Tsai, B. Friedman, V. Lev-Ram, Q. Xiong, R. Y. Tsien, D.
Kleinfeld, A. I. Ifarraguerri, B. D. Thompson and J. A. Squier.
In Proceedings of CLEO, Baltimore, MD (2003).
PDF
(0.7 Mb)
All optical thrombotic stroke model for near-surface
blood vessels in rat: Focal illumination of exogenous photosensitizers
combined with real-time two-photon imaging. C. B. Schaffer,
P. S. Tsai, N. Nishimura, L. F. Schroeder, B. Friedman, P. D.
Lyden, F. F. Ebner and D. Kleinfeld. In Proceedings of
the SPIE/Photonics West (Commercial and Biomedical
Applications of Ultrafast Lasers III, J. Neev, A. Osterdof and
C. B. Schaffer, editors), San Jose, CA (2003) pp 222-231.
PDF
(2.5 Mb)
Traveling electrical waves in cortex: Measurements with
optical imaging techniques and insights from phase dynamics.
D. Kleinfeld. In Proceedings of the SPIE, San Diego, CA (2001).
PDF
(0.1 Mb)
(1996 - 2000)
Anatomical loops and their electrical dynamics in relation to whisking
by rat. D. Kleinfeld, R. W. Berg and S. M. O'Connor.
In Proceedings of Barrels XI. Somatosensory and Motor Research
(1999) 16:163-164.
In vivo imaging of electrical activity in vibrissa cortex.
D. Kleinfeld. In Proceedings of Barrels X. Somatosensory
and Motor Research (1998) 15:00.
Natural stimuli induce waves of electrical activity in
visual cortex in turtle. D. Kleinfeld, and J. C. Prechtl.
In Proceedings of Neural Information Processing Systems
XII, Breckenridge, CO (1997) 12:00.
Motor modulation of sensory input: Exploratory whisking
by rat as a model system. D. Kleinfeld, P. P. Mitra and
M. S. Fee. In Proceedings of Barrels IX. Somatosensory
and Motor Research (1997) 14:63.
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